Endocrine Abstracts

Purpose: Recently, apatinib, an orally anti-angiogenic tyrosine kinase inhibitor (TKI) is reported to be useful for treatment of progressive RAIR-DIC. The aim of this study was to evaluate the effect of apatinib and the combination therapy with radioactive iodine (RAI) in patients with progressive metastatic DTC.Methods: Five patients (all female mean age 62 ± 8 years, ranged from 51 to 69 years) with progressive distant metastatic DTC (dmDTC) after t...

Objectives: We previously reported the outcome of 1-year follow-up of 2013 DTC patients in the DTCC (differentiated thyroid cancer in China) 1st stage Study. Using the retrospectively gathered information, we sought to observe the long-term follow-up and prognosis of these patients with DTC undergoing thyroid surgery.Methods: This multicenter, noninterventional study was conducted at eight tertiary hospitals across China. Data from the patient...

The islet-enriched transcription factor MAFA regulates the expression of genes critical to beta cell function and insulin secretion. We previously described anovel MAFA mutation (c.191C > T, p.S64F) causing familial insulinomatosis and diabetes mellitus, with male carriers more often developing diabetes and females more prone to insulinomatosis. The exact molecular mechanisms underlying these phenotypes are unclear. In this study, we assessed glucose metabolism an...